The Hyatt Regency Thessaloniki is 13 km from the city center. It is adjacent to the Regency Casino, and guests are also within 10 minutes of the beaches and the White Tower. The Hyatt Regency Thessaloniki is five minutes drive from the airport and about 15 minutes' drive from the central downtown area. The hotel operates a complimentary shuttle service to and from the airport for guests.

Guests will find the Hyatt Regency Thessaloniki offers rooms with air conditioning and modern furniture with Greek accents. There are 152 rooms in all, with balconies. Satellite television service, Internet access, safe boxes, mini bars, and en suite bathrooms with hair dryers complete the amenities.

The Hyatt Regency Thessaloniki is an upscale business and leisure property with modern amenities. The property has a high-tech conference room for business events or social needs, and there is a business support center on site. The house restaurant serves Mediterranean dishes and there is a lounge bar in the lobby. Club Olympus on site offers spa and wellness services, and there is a workout room. Parking is offered to guests with cars.